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FAILURE OF 2‐HYDROXYOESTRONE TO LOWER PROLACTIN CONCENTRATIONS IN HYPERPROLACTINAEMIC WOMEN
Author(s) -
FRANKS S.,
LIGHTMAN S. L.,
MACLUSKY N. J.,
NAFTOLIN F.,
LYNCH S. S.,
BUTT W. R.,
JACOBS H. S.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00678.x
Subject(s) - hyperprolactinaemia , prolactin , endocrinology , medicine , anovulation , secretion , estrone , hormone , polycystic ovary , diabetes mellitus , insulin resistance
SUMMARY The catechol oestrogen 2‐hydroxyoestrone has been reported to lower serum prolactin concentrations acutely in normal women and it has been proposed that it may be effective in suppressing prolactin secretion in hyperprolactinaemic patients. Five women with hyperprolactinaemia and anovulation were studied. Following a control infusion, 2‐hydroxyoestrone was given at a rate of 80 μg/h for 4 h. In no patient was there a fall in prolactin levels and no changes were observed in gonadotrophin concentrations. We conclude that a short‐term infusion of 2‐hydroxyoestrone, at a dose which will produce high blood levels of the steroid, does not affect prolactin or gonadotrophin secretion in hyperprolac‐tinaemic states.