Premium
ALLOSUPPRESSOR T LYMPHOCYTES ABOLISH MIGRATION INHIBITION FACTOR PRODUCTION IN AUTOIMMUNE THYROID DISEASE: EVIDENCE FROM RADIOSENSITIVITY EXPERIMENTS
Author(s) -
TOPLISS D. J.,
OKITA N.,
LEWIS M.,
ROW V. V.,
VOLPÉ R.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00673.x
Subject(s) - endocrinology , medicine , t lymphocyte , antigen , thyroiditis , radiosensitivity , in vitro , thyroid , immunology , suppressor , lymphocyte , biology , biochemistry , cancer , radiation therapy
SUMMARY The ability of normal T lymphocytes to abolish the production of migration inhibition factor by antigen‐sensitized T lymphocytes of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in response to thyroid antigen has been studied by a modified migration inhibition factor test using isolated T lymphocytes alone. The production of migration inhibition factor was consistently abolished when normal T lymphocytes were mixed with GD or HT T lymphocytes in various ratios (1:9, 2:8, 5:5) as reported previously (Okita et al. , 1980b). However, prior in‐vitro irradiation (1000 rad) of the normal T lymphocytes resulted in loss of their ability to abolish migration inhibition factor production by the antigen‐sensitized T lymphocytes of GD and HT. The effect is consistent with the radiosensitivity of suppressor T lymphocytes and indicates that the effect of normal T lymphocytes on GD and HT T lymphocytes is one of allosuppression. The results support the view that there is a defect in suppressor T cell function in GD and HT.