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THE EFFECT OF WEIGHT LOSS ON SEX STEROID SECRETION AND BINDING IN MASSIVELY OBESE WOMEN
Author(s) -
KOPELMAN P. G.,
WHITE N.,
PILKINGTON T. R. E.,
JEFFCOATE S. L.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00644.x
Subject(s) - endocrinology , medicine , androstenedione , sex hormone binding globulin , sex steroid , testosterone (patch) , steroid , hormone , steroid hormone , weight loss , biology , obesity , androgen
SUMMARY We have previously reported increased testosterone and androstenedione concentrations and decreased sex hormone binding globulin (SHBG) concentrations in the plasma of massively obese women. We now report that these plasma hormone concentrations return to normal in twelve of the same women after substantial weight reduction and these changes are associated with more normal menstrual cycles. We conclude that body weight and fat are important determinants of sex steroid secretion and binding and thus influence menstrual function.