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EFFECT OF EXOGENOUS INSULIN ON FASTING SERUM LEVELS OF GASTRIC INHIBITORY POLYPEPTIDE (GIP) IN JUVENILE DIABETES
Author(s) -
TALAULICAR M.,
EBERT R.,
WILLMS B.,
CREUTZFELDT W.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00613.x
Subject(s) - medicine , endocrinology , insulin , gastric inhibitory polypeptide , basal (medicine) , diabetes mellitus , glucagon
SUMMARY The effect of insulin on fasting levels of immunoreactive gastric inhibitory polypeptide (IR‐GIP) has been examined in insulin‐dependent, juvenile‐type diabetics who were well‐controlled with two doses of an intermediate insulin. After withdrawal of the evening insulin injection the fasting blood glucose and serum IR‐GIP levels were elevated and decreased significantly following intravenous insulin towards normal values. There was a significant positive correlation between levels of blood glucose and serum IR‐GIP before and during insulin application. It is suggested that fasting serum GIP levels increase in case of insulin deficiency because basal GIP secretion is suppressed by normal insulin levels.