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FAILURE OF HAEMAGGLUTINATION AND IMMUNOFLUORESCENCE METHODS TO DETECT SERUM ORBITAL ANTIBODIES IN PATIENTS WITH GRAVES' OPHTHALMOPATHY
Author(s) -
HENDERSON JANICE,
WALL J. R.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00610.x
Subject(s) - autoantibody , hemagglutination , graves' ophthalmopathy , pathogenesis , immunofluorescence , antibody , medicine , anti thyroid autoantibodies , antigen , endocrinology , guinea pig , graves' disease , immunology , thyroid
SUMMARY Serum antibodies against human, bovine, and guinea‐pig, orbital antigens were tested for in patients with Graves' ophthalmopathy using haemagglutination and immunofluorescence techniques. Although low titres of antibodies were demonstrated in a small proportion of patients with Graves' ophthalmopathy, the prevalence was similar to that for normal subjects using both tests. The significance of these findings and the evidence for a role of autoantibodies in the pathogenesis of Graves' ophthalmopathy are discussed.