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VITAMIN D METABOLITES AND THEIR RELATIONSHIP TO AZOTAEMIC OSTEODYSTROPHY *
Author(s) -
MASON REBECCA S.,
LISSNER DIANNE,
WILKINSON MARGARET,
POSEN S.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb03399.x
Subject(s) - osteomalacia , medicine , endocrinology , vitamin d and neurology , creatinine , metabolite , renal osteodystrophy , vitamin d deficiency , parathyroid hormone , calcifediol , chemistry , kidney disease , calcium
SUMMARY Bone biopsies were performed and serum concentrations of vitamin D metabolites were measured in twenty‐four patients with chronic renal failure. The concentrations of three metabolites‐25‐dihydroxyvitamin D (25‐OHD). 24,25‐dihydroxyvitarnin D (24,25‐OH 2 D) and 1,25‐dihydroxyvitamin D (1,25‐OH 2 D)‐were significantly lower in uraemic than in normal sera. There was a positive correlation between serum 24,25‐OH 2 D and serum 25‐OHD, whereas serum 1,25‐OH 2 D values, which were independent of those of the other vitamin D metabolites, were negatively correlated with serum creatinine and serum inorganic phosphate. The two major skeletal lesions, osteomalacia and parathyroid osteopathy, while coexisting in many patients, varied independently in relation to their severity and were correlated with different vitamin D metabolites. The severity of osteomalacia was negatively correlated with the serum concentrations of 25‐OHD and 24,25‐OH 2 D while the severity of parathyroid osteopathy was negatively correlated with serum 1,25‐OH 2 D values. To our knowledge these are the first systematic studies correlating skeletal histology with dihydroxylated vitamin D metabolites in renal failure in man.