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FAILURE OF BOMBESIN TO ALTER ANTERIOR PITUITARY HORMONE SECRETION IN MAN
Author(s) -
MORLEY J. E.,
VARNER A. A.,
MODLIN I. M.,
CARLSON H. E.,
BRAUNSTEIN G. D.,
WALSH J. H.,
HERSHMAN J. M.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb03398.x
Subject(s) - medicine , endocrinology , anterior pituitary , bombesin , secretion , hormone , neuroendocrinology , pituitary gland , somatotropic cell , peptide hormone , biology , receptor , neuropeptide
SUMMARY Because of the stimulating effects of bombesin on growth hormone and prolactin secretion in the rat, we have studied the effects of bombesin infusions on anterior pituitary hormone secretion in man. Biological activity of the infused bombesin was confirmed by observing a brisk increase in serum gastrin concentrations and in gastric acid secretion during the lowest dose of bombesin infused. We could demonstrate no effect of bombesin in doses from 200 to 600 pmol.kg −1 .h −1 on growth hormone, prolactin, thyrotrophin, luteinizing hormone and follicle stimulating hormone.