Premium
DYNAMICS OF SERUM rT3 AND 3, 3‐T2 DURING rT3 INFUSION IN PATIENTS TREATED FOR THYROTOXICOSIS WITH PROPYLTHIOURACIL OR METHIMAZOLE
Author(s) -
LAURBERG P.,
WEEKE J.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb03133.x
Subject(s) - propylthiouracil , methimazole , medicine , endocrinology , metabolic clearance rate , antithyroid agent , graves' disease , thyroid , pharmacokinetics
SUMMARY rT3 metabolism in patients treated for thyrotoxicosis with propylthiouracil (PTU), or methimazole (MMI) was studied by infusion of rT3 and measurements of the increase in serum rT3 and serum 3, 3′‐diiodothyronine. The results indicate that the high serum rT3 observed during treatment with PTU is not due to an increase in rT3 production, but to a decrease in the metabolic clearance rate of rT3. rT3 infusion was followed by an increase in serum 3, 3′‐T2 which was similar whether PTU or MMI was given. However, after stopping rT3 infusion there was a more rapid fall in serum 3, 3′‐T2 during MMI treatment, compatible with an inhibitory effect of PTU on 3, 3′‐T2 degradation.