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GROWTH HORMONE CELL ANTIBODIES AND PARTIAL GROWTH HORMONE DEFICIENCY IN A GIRL WITH TURNER'S SYNDROME
Author(s) -
BOTTAZZO G. F.,
McINTOSH C.,
STANFORD W.,
PREECE M.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb03126.x
Subject(s) - endocrinology , medicine , turner syndrome , growth hormone , growth hormone deficiency , girl , hormone , short stature , autoimmunity , bone age , biology , disease , genetics
SUMMARY Growth hormone (GH) cell auto‐antibodies have been demonstrated in the serum of a girl with an iso‐chromosome variant of Turner's syndrome. On two occasions she showed an abnormal response of GH release during insulin induced hypoglycaemia. Her response to GH treatment was poor, but this was commenced at a very late bone‐age. It is possible that autoimmunity is a new aetiological factor for GH deficiency in some cases.