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STUDIES ON THE ROLE OF HISTAMINE IN HUMAN PITUITARY FUNCTION
Author(s) -
CARLSON HAROLD E.,
CHANG R. JEFFREY
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb02736.x
Subject(s) - endocrinology , medicine , histamine , function (biology) , pituitary gland , chemistry , biology , hormone , microbiology and biotechnology
To elucidate further the role of histamine in pituitary regulation, TRH and L‐DOPA stimulation tests were performed with and without diphenhydramine, cimetidine, or betazole pre‐treatment. Betazole blunted the GH response to L‐DOPA and slightly enhanced the T3 response to TRH without altering the TSH or PRL increments. Neither diphenhydramine nor cimetidine had any acute effect on the hormonal responses examined. Histamine appears to play only a limited role in these aspects of human pituitary regulation.