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INHIBITION OF PROLACTIN SECRETION BY NOMIFENSINE IN MAN
Author(s) -
MASALA A.,
ALAGNA S.,
DEVILLA L.,
DELITALA G.,
ROVASIO P. P.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb02705.x
Subject(s) - nomifensine , prolactin , endocrinology , medicine , secretion , endogeny , reuptake , prolactin cell , catecholamine , chemistry , dopamine , hormone , serotonin , receptor , dopaminergic
Serum prolactin, TSH and GH levels were measured in thirty healthy volunteers in fasting conditions and following oral administration of 200 mg nomifensine. In addition, the effect of the drug on serum prolactin and TSH response to synthetic TRH was studied in twenty normal subjects. Inhibition of endogenous catecholamine reuptake by nomifensine significantly inhibited prolactin release whereas it had no effect on TSH and GH levels. Nomifensine administration had no appreciable effect on the TRH‐induced release of TSH and prolactin.