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ENDOCRINE INFLUENCES ON SERUM ACID‐ETHANOL SOLUBLE NON‐SUPPRESSIBLE INSULIN‐LIKE ACTIVITY (NSILA‐S)
Author(s) -
FRANKLIN R. C.,
RENNIE G. C.,
BURGER H. G.,
CAMERON D. P.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb02127.x
Subject(s) - medicine , endocrinology , endocrine system , insulin , ethanol , chemistry , biochemistry , hormone
SUMMARY Serum levels of the acid‐ethanol soluble component of non‐suppressible insulin‐like activity (NSILA‐S) have been measured by bioassay in patient with hyperprolactinaemia, hypothyroidism, thyrotoxicosis and diabetes mellitus, and in normal subjects administered prednisone, oestrogens or androgens. Hyperprolactinaemia per se did not influence serum NSILA‐S, however when GH was deficient prolactin hypersecretion may have maintanied serum NSILA‐S. Thyroid hormones, insulin and steroids did not appear to influence serum NSILA‐S. These results suggest that regulation of the serum concentration of NSILA‐S is not a common effector mechanism by which these hormones influence statural growth in man.