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CIRCULATING SOMATOSTATIN AFTER FOOD AND GLUCOSE IN MAN
Author(s) -
WASS J. A. H.,
PENMAN ERICA,
DRYBURGH JILL R.,
TSIOLAKIS D.,
GOLDBERG P. L.,
DAWSON A.M.,
BESSER G. M.,
REES LESLEY H.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb01377.x
Subject(s) - somatostatin , medicine , endocrinology , biology
SUMMARY Using a recently validated radioimmunoassay, changes in circulating somatostatin have been measured in normal subjects after food (a standard breakfast), and oral and intravenous glucose. After the standard breakfast, a clear and sustained rise in plasma somatostatin was seen in all subjects from a mean value (± 1 SE) of 28 ± 7 pg/ml to a mean peak value, at 60 min of 57 ± 11 pg/ml. When glucose was taken by mouth a significant but smaller rise was seen, but intravenous glucose caused no significant change in plasma somatostatin. A rise in circulating somatostatin after feeding has not previously been demonstrated in normal man and it is suggested that somatostatin may have an important endocrine role in the gut.