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THE EFFECT OF CYPROTERONE ACETATE ON SERUM TESTOSTERONE, LH, FSH, AND PROLACTIN IN MALE SEXUAL OFFENDERS
Author(s) -
JEFFCOATE W. J.,
MATTHEWS R. W.,
EDWARDS C. R. W.,
FIELD L. H.,
BESSER G. M.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb01041.x
Subject(s) - cyproterone acetate , medicine , endocrinology , cyproterone , luteinizing hormone , testosterone (patch) , prolactin , follicle stimulating hormone , androgen , hormone
SUMMARY The anti‐androgen, cyproterone acetate, was administered in a dose of 100 mg/day to eight adult male sexual offenders for 21–31 days. Serum testosterone fell to subnormal levels within 7 days and remained low for 6–28 days after treatment was stopped. The fall in testosterone was accompanied by a fall in serum luteinizing hormone (LH) and follicle stimulating hormone (FSH), and a rise in serum prolactin. All subjects experienced a decrease in libido and in frequency of masturbation. The probable mechanisms of action of cyproterone acetate are discussed, as is its potential role in the management of sexual offenders. These studies suggest that measurement of serum testosterone could be used as an index of compliance in sexual offenders treated with cyproterone acetate who are released on parole.

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