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IN VIVO AND IN VITRO STUDIES ON THE EFFECT OF METOCLOPRAMIDE ON ALDOSTERONE SECRETION
Author(s) -
EDWARDS C. R. W.,
ALDUJAILI E. A. S.,
BOSCARO M.,
QUYYUMI S.,
MIALL P. A.,
REES LESLEY H.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb01021.x
Subject(s) - metoclopramide , aldosterone , endocrinology , medicine , in vivo , secretion , in vitro , chemistry , biology , biochemistry , microbiology and biotechnology , vomiting
SUMMARY Metoclopramide, a dopamine antagonist drug, elevated plasma aldosterone and prolactin levels without significantly affecting plasma renin activity, ACTH or potassium. Studies with isolated perfused rat zona glomerulosa cells showed that metoclopramide could directly stimulate aldosterone release and that this action was blocked by dopamine. These results suggest that dopamine may play an important inhibitory role in the control of aldosterone secretion.