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EFFECTS OF SULPIRIDE INDUCED HYPERPROLACTINAEMIA IN PATIENTS WITH TURNER'S SYNDROME
Author(s) -
LOLI P.,
RIOLO A.,
BONOMO M.,
RONZONI M.,
BOTALLA L.,
GELLI D.
Publication year - 1980
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1980.tb01017.x
Subject(s) - hyperprolactinaemia , sulpiride , endocrinology , medicine , turner syndrome , prolactin , antagonist , receptor , hormone
SUMMARY In order to evaluate the interference of prolactin (PRL) on some aspects of pituitary‐gonadal derangement observed in patients with hyperprolactinaemic amenorrhoea (HA), a GnRH stimulation test (100 μg i.v.) was performed on twenty‐one patients with hyperprolactinaemia without evidence of pituitary tumour and in nine subjects with Turner's syndrome (TS) before and after sulpiride administration (200 mg/day orally, for 3 months). In patients with HA an enhanced response of gonadotrophins to GnRH was observed. In patients with TS a further increase of the gonadotrophin hyper‐responsiveness to the releasing hormone occurred when hyperprolactinaemia was induced by chronic sulpiride administration. Since, in these patients, appreciable ovarian steroido‐genesis is lacking, a direct effect of the increased plasma PRL at the hypothalamo‐pituitary level is likely. In hyperprolactinaemic amenorrhoea pituitary hyper‐responsiveness may not be due to PRL effect on ovarian steroidogenesis.