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IMMUNOREACTIVE SOMATOMEDIN B IN ACROMEGALY AND IN TURNER'S SYNDROME
Author(s) -
BENKER G.,
SPIRA G.,
ZÄH W.,
THARANDT L.,
HACKENBERG K.,
REINWEIN D.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03086.x
Subject(s) - acromegaly , endocrinology , somatomedin , medicine , turner syndrome , turner's syndrome , growth hormone , hormone
SUMMARY Serum somatomedin B was measured by radioimmunoassay in forty‐seven normal subjects, twenty‐nine patients with acromegaly before and twenty‐four after treatment, and eighteen patients with Turner's syndrome. Somatomedin B levels were significantly elevated in untreated acromegaly and in Turner's syndrome compared with the control group; they decreased following treatment of acromegaly. Because of the overlap between the groups, little information could be obtained from single somatomedin B estimations, which could, therefore, not replace dynamic tests of growth hormone secretion. No correlation between growth hormone and somatomedin B in acromegaly was detected; however, somatomedin B appeared to be related to the insulin response during the oral glucose tolerance test. In Turner's syndrome, no relationship between somatomedin B and insulin production, urinary oestrogen excretion, growth hormone secretion, gonadotrophin levels, age or height was found. The reason for the raised somatomedin B levels in Turner's syndrome remains at present unknown.