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EFFECTS OF LONG‐TERM TREATMENT WITH METERGOLINE IN PATIENTS WITH IDIOPATHIC OLIGOSPERMIA
Author(s) -
MASALA A.,
DELITALA G.,
ALAGNA S.,
DEVILLA L.,
ROVASIO P.P.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03084.x
Subject(s) - metergoline , medicine , oligospermia , endocrinology , term (time) , biology , pregnancy , receptor , infertility , azoospermia , 5 ht receptor , serotonin , genetics , physics , quantum mechanics
SUMMARY The effect of metergoline, an ergoline derivative with antiserotonin as well as dopaminergic properties, was studied in forty‐five male patients with idiopathic oligospermia. Metergoline treatment (6 mg daily for 5 months) had no demonstrable effect on spermatogenesis; moreover, it did not influence the serum levels of LH, FSH, testosterone and oestradiol although it significantly reduced prolactin levels. It is concluded that, in all likelihood, serotonin plays little or no part in the pathogenesis of idiopathic oligospermia and that pharmacological reduction of normal prolactin levels has no therapeutic effect on this disease.