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EVALUATION OF RESECTION OF PITUITARY MICROADENOMA FOR THE TREATMENT OF CUSHING'S DISEASE IN PATIENTS WITH RADIOLOGICALLY NORMAL SELLA TURCICA
Author(s) -
WAJCHENBERG B. L.,
SILVEIRA A. A.,
GOLDMAN J.,
CESAR F. P.,
MARINO R.,
LIMA S. S.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03081.x
Subject(s) - sella turcica , medicine , hypophysectomy , adenoma , pituitary adenoma , pituitary gland , cyproheptadine , resection , cushing's disease , pituitary disease , transsphenoidal surgery , surgery , disease , hormone , receptor , serotonin
SUMMARY Si.: patients with Cushing's disease and a radiologically normal sella turcica have been treated by transsphenoidal hypophysectomy. Microadenomas were found and removed in five. One patient was in complete remission by 2 months and three by 6 months post‐operatively. Two of the remaining patients (one with and the other without a surgically demonstrable tumour) were not cured after 8 and 15 months follow‐up, respectively. Our data suggest that pituitary tumours are present in the majority of patients with Cushing's disease. The possibilities of incomplete adenomectomy or of a tumour buried within the gland should be considered in patients in whom pituitary surgery does not induce remission. In one patient, subsequently proven to have a pituitary adenoma, the disease remitted pre‐operatively with cyproheptadine, suggesting hypothalamic regulation of the tumour and/or direct drug action at the pituitary level.