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MODIFICATION OF THE NORMAL POSTURAL CHANGES IN PLASMA RENIN ACTIVITY BY THE APPLICATION OF POSITIVE PRESSURE TO THE LEGS
Author(s) -
MCGIVERN D.,
HARDCASTLE A.,
MILLAR J. G. B.,
WARREN D. J.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03053.x
Subject(s) - plasma renin activity , medicine , endocrinology , blood pressure , renin–angiotensin system , basal (medicine) , heart rate , plasma volume , blood volume , insulin
SUMMARY In six normal male subjects plasma renin activity (PRA) rose progressively on standing over a 2 hour period. PRA fell to basal levels after a further 2 hours of recumbency. The rate of rise of PRA on standing was largely abolised following the application of an anti‐gravity (‘G’) suit. Continuous monitoring of blood pressure (BP) heart rate (HR) and packed cell volume (PCV) suggest that it is the fall in effective blood volume which elicits the stimuli to renin release during changes in posture.