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INDUCTION OF PUBERTY LONG‐TERM TREATMENT WITH HIGH‐DOSE LHRH
Author(s) -
BROOK C. G. D.,
DOMBEY S.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03049.x
Subject(s) - hypogonadotrophic hypogonadism , medicine , endocrinology , delayed puberty , hormone , sex steroid , testosterone (patch) , steroid
SUMMARY Gonadotrophin releasing hormone 500 mcg was administered twice daily to four patients (two male, two female) with hypogonadotrophic hypogonadism due to LHRH deficiency, for a minimum of 1 year. Despite initially encouraging biochemical responses and physical changes in all four patients, gonadotrophin responsiveness waned, sex steroid levels were not maintained and pubertal development has not occurred. This diminishing responsiveness appears to be a severe limitation on the use of LHRH as a therapeutic agent.