Premium
ACROMEGALY DUE TO PRODUCTION OF A GROWTH HORMONE RELEASING FACTOR BY A BRONCHIAL CARCINOID TUMOUR
Author(s) -
SHALET S. M.,
BEARDWELL C. G.,
MacFARLANE I. A.,
ELLISON M. L.,
NORMAN C. M.,
REES L. H.,
HUGHES M.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03034.x
Subject(s) - acromegaly , carcinoid tumour , medicine , growth hormone , endocrinology , hormone
SUMMARY We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperoxidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary mono‐layer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a patient with the clinical and biochemical manifestations of excess growth hormone production.