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EFFECTS OF HEROIN ADDICTION ON THYROTROPHIN, THYROID HORMONES AND PROLACTIN SECRETION IN MEN
Author(s) -
CHAN VIVIAN,
WANG CHRISTINA,
YEUNG ROSE T. T.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb02115.x
Subject(s) - endocrinology , medicine , prolactin , secretion , hormone , thyroid hormones , heroin addiction , thyroid , heroin , drug , pharmacology
SUMMARY Pituitary‐thyroid function in male heroin addicts and addicts after abstinence (exaddicts) was studied and compared with that of healthy euthyroid men. In heroin addicts the increases in circulating total thyroxine and triiodothyronine levels were accompanied by an increase in the thyroid hormone uptake test. These changes may reflect a quantitative increase in thyroxine binding globulin. Reverse triiodothyronine concentrations in heroin addicts were normal. The thyrotrophin‐releasing hormone elicited a diminished thyrotrophin response in heroin addicts which was significantly different from that in control subjects and ex‐addicts. An elevation of serum prolactin was noted in heroin addicts, while ex‐addicts had normal levels. Gradual recovery of pituitary‐thyroid function occurred after heroin withdrawal.