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PLASMA CYCLIC‐AMP RESPONSE TO PARATHYROID HORMONE IN TURNER'S SYNDROME AND ALBRIGHT'S HEREDITARY OSTEODYSTROPHY
Author(s) -
ASHBY J.P.,
RENTON W. B.,
MACPHERSON J.N.,
PRICE W. H.,
ABBOTT S. R.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb02114.x
Subject(s) - pseudohypoparathyroidism , endocrinology , medicine , turner syndrome , parathyroid hormone , osteodystrophy , brachydactyly , urinary system , calcium , short stature
SUMMARY Purified bovine parathyroid hormone (BPTH) given by injection to five patients with Turner's syndrome, and seven healthy volunteers produced a significant rise in plasma cyclic AMP reaching a maximum within 10 min. In a pseudohypoparathyroid patient there was no increase. Urinary excretion of cyclic AMP exceeded the normal in three out of four patients with Turner's syndrome. Thus, if there is a relationship between Turner's syndrome and Albright's osteodystrophy it is with the incomplete form known as pseudo‐pseudohypoparathyroidism.