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NON‐PROTEIN‐BOUND OESTROGENS IN PLASMA AND URINARY EXCRETION OF UNCONJUGATED OESTROGENS IN MEN
Author(s) -
SPEIGHT ALISON C.,
HANCOCK K. W.,
OAKEY R. E.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb02088.x
Subject(s) - medicine , endocrinology , chemistry , urine , excretion , blood proteins
SUMMARY Unconjugated oestrone and unconjugated oestradiol‐17β were measured in 24 h urine specimens from twenty normal men. The concentrations of non‐protein‐bound oestrone and non‐protein‐bound oestradiol‐17β, in samples of blood obtained from these subjects during the time in which the urine was collected, were measured by equilibrium dialysis (using a correction for plasma dilution). The mean excretion of unconjugated oestrone (0.44 ± 0.36 nmol/24 h, mean ± SD) was significantly greater ( P < 0.01) than that of unconjugated oestradiol‐17β (0.20 ± 0.13 nmol/24 h). The concentrations of non‐protein‐bound oestrone and non‐protein‐bound oestradiol‐17β in plasma were 5.52 ± 2.69 pmol/1 and 2.42 + 0.73 pmol/l, respectively. There was no correlation between the quantity of unconjugated oestrone excreted and the concentration of non‐protein‐bound oestrone in plasma ( r = 0.27) nor between the quantity of unconjugated oestradiol‐17β in the urine and the concentration of non‐protein‐bound oestradiol‐17β in plasma ( r = 0.05). Therefore in normal men, estimation of unconjugated oestrone or oestradiol‐17β in urine provides no guide to the concentration of the corresponding non‐protein‐bound oestrogen in plasma.