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FUNCTIONAL SIGNIFICANCE OF ANTIBODY FORMATION AFTER LONG‐TERM SALMON CALCITONIN THERAPY
Author(s) -
HOSKING D. J.,
DENTON L. B.,
CADGE B.,
MARTIN T. J.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb02078.x
Subject(s) - endocrinology , medicine , salmon calcitonin , calcitonin , term (time) , antibody , immunology , physics , quantum mechanics
SUMMARY Twenty patients with Paget's disease were challenged with porcine (PCT) and salmon (SCT) calcitonin before and after 6 months SCT therapy. Acute hypocalcaemia was clearly related to the prevailing rate of bone turnover but responses to PCT showed that treatment had not disturbed this relationship. Although antibodies to SCT developed in eight patients during the period of treatment the acute hypocalcaemic response to SCT was not diminished in relation to bone turnover. It is suggested that antibodies which develop during the course of SCT therapy do not necessarily exert a functionally effective neutralizing action.