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THE EFFECTS OF DOPAMINE, BROMOCRIPTINE, LERGOTRILE AND METOCLOPRAMIDE ON PROLACTIN RELEASE FROM CONTINUOUSLY PERFUSED COLUMNS OF ISOLATED RAT PITUITARY CELLS
Author(s) -
YEO T.,
THORNER M. O.,
JONES ANN,
LOWRY P. J.,
BESSER G. M.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb01357.x
Subject(s) - bromocriptine , metoclopramide , endocrinology , medicine , prolactin , dopamine , chemistry , phenoxybenzamine , propranolol , hormone , vomiting
SUMMARY The control of secretion of prolactin was studied using continuous perfusion of a column of isolated rat pituitary cells supported by Bio‐Gel polyacrylamide beads. Prolactin secretion was inhibited repeatedly by dopamine and rapidly recovered in its absence. Maximum inhibition was achieved at 5 ± 10 7 M dopamine. Bromocriptine and lergotrile directly inhibited prolactin release from the pituitary cells. Bromocriptine had a longterm action in inhibiting secretion. The dopamine receptor blocking agent, metoclopramide, overcame the inhibitory effect of dopamine but had no effect on prolactin secretion in its absence.