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THE EFFECT OF PROPRANOLOL ON THYROID HORMONES AND OXYGEN CONSUMPTION IN THYROTOXICOSIS
Author(s) -
SAUNDERS J.,
HALL SUSAN E. H.,
CROWTHER A.,
SÖNKSEN P. H.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb03573.x
Subject(s) - propranolol , endocrinology , medicine , hormone , oxygen , thyroid , thyroid hormones , iodine , chemistry , organic chemistry
SUMMARY The possibility that propranolol may exert its beneficial actions in thyrotoxicosis by an effect on thyroid hormone concentrations has been investigated by measuring these and oxygen consumption in a group of thyrotoxic patients before and after treatment with propranolol. Following treatment a significant fall in plasma T3 concentration and oxygen consumption occurred and a direct correlation was found between these two variables. Propranolol may, therefore, exert some of its beneficial effects in thyrotoxicosis by an action on T3 metabolism.