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‘LOW T3 SYNDROME’ IN PATIENTS CHRONICALLY TREATED WITH AN IODINE‐CONTAINING DRUG, AMIODARONE
Author(s) -
JONCKHEER M. H.,
BLOCKX P.,
BROECKAERT I.,
CORNETTE C.,
BECKERS C.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb03569.x
Subject(s) - amiodarone , euthyroid , medicine , iodine , endocrinology , drug , thyroid function , thyroid , thyroid function tests , chemistry , pharmacology , organic chemistry , atrial fibrillation
SUMMARY Cardiac patients treated with the iodinecontaining drug ‘amiodarone’ undergo a significant iodine overload whch can last for months after the drug has been withdrawn. Some patients develop hyperthyroidism and others hypothyroidism. In the hyper‐ or hypothyroid patients, the indices of thyroid function are modified as usually observed in these situations. In the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the iodine overload, a ‘low‐T3 syndrome’ is observed, this state being characterized by a high total T4, a low free T4, a normal T3 resin uptake, a low total T3, a normal free T3, a high r‐T3 and a relative TSH‐unresponsiveness to TRH.