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DISCREPANCY BETWEEN ACTH AND CORTISOL RESPONSES TO INSULIN INDUCED HYPOGLYCAEMIA
Author(s) -
LINDHOLM JÖRGEN,
KEHLET HENRIK,
BLICHERTTOFT MOGENS,
RIISHEDE JOHN,
HUMMER LOTTE,
DINESEN BO
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb02222.x
Subject(s) - medicine , endocrinology , adrenal cortex , insulin , acth secretion , hydrocortisone , secretion , adrenocorticotropic hormone , hormone
SUMMARY The purpose of this study was to assess the normal relationship between plasma ACTH and cortisol during insulin induced hypoglycaemia. Twenty‐six healthy persons were studied. Peak plasma concentration and the amounts of ACTH and cortisol secreted during hypoglycaemia were compared. There was no significant correlation between the ACTH and cortisol values. The ACTH responses varied significantly more than those of cortisol. This probably signifies an overcapacity of ACTH secretion in comparison to the secretory capacity of the adrenal cortex.