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A LOW T3 SYNDROME IN DIABETIC KETOACIDOSIS
Author(s) -
NAEIJE R.,
GOLSTEIN J.,
CLUMECK N.,
MEINHOLD H.,
WENZEL K. W.,
VANHAELST L.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb02183.x
Subject(s) - medicine , endocrinology , triiodothyronine , euthyroid , diabetic ketoacidosis , reverse triiodothyronine , thyroid function , diabetes mellitus , thyroid , hormone , ketoacidosis , euthyroid sick syndrome , thyroid function tests , type 1 diabetes
SUMMARY The pituitary‐thyroid axis was investigated in nineteen euthyroid patients with severe diabetic ketoacidosis. A ‘low T3 syndrome’ was found, with the following characteristics: lowered serum concentrations of triiodothyronine (T3), increased reverse triiodothyronine (rT3), slightly low thyroxine (T4), normal thyrotrophin (TSH), slightly increased triiodothyronine uptake (RT3U) values, and a blunted TSH response to thyrotrophin‐releasing hormone (TRH). These disturbances in thyroid‐function tests required several days good control of the diabetes to be corrected, at least partially. The data suggest the presence of an abnormal extrathyroidal T4 metabolism as well as a pituitary defect. Caution is recommended in the interpretation of thyroid‐function tests during and several days after the treatment of diabetic ketoacidosis.