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24 HOUR PROFILE OF 18‐HYDROXY‐11‐DEOXYCORTICOSTERONE IN NORMAL SUPINE MAN: RELATIONSHIP WITH CORTISOL AND ALDOSTERONE
Author(s) -
SULON J.,
SPARANO F.,
SCIARRA F.,
GIAQUINTO G.,
GENARD P.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb02170.x
Subject(s) - endocrinology , medicine , aldosterone , supine position , hydrocortisone , mineralocorticoid
SUMMARY Daily profiles of plasma 18‐hydroxy‐11‐deoxycorticosterone (18‐OH‐DOC) were studied in four normal supine men on a normal sodium intake. Blood was taken every hour from 01.00 to 24.00 hours. Plasma cortisol (F) and aldosterone (A) were determined hourly for comparative studies. 18‐OH‐DOC fluctuated considerably during the 24 h period of investigation, the highest values being found during the early morning hours in synchrony with F. The episodic secretions of 18‐OH‐DOC were also significantly correlated with those of A, which in turn paralleled those of F. We conclude that ACTH, plays a definite role in the regulation of 18‐OH‐DOC in normal supine men on a normal sodium diet.