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THE INTER‐RELATIONSHIP OF THYROID HORMONES, VITAMIN A AND THEIR BINDING PROTEINS FOLLOWING ACUTE STRESS
Author(s) -
RAMSDEN D. B.,
PRINCÉ H. P.,
BURR W. A.,
BRADWELL A. R.,
BLACK E. G.,
EVANS A. E.,
HOFFENBERG R.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb02159.x
Subject(s) - medicine , endocrinology , retinol binding protein , euthyroid , transthyretin , retinol , triiodothyronine , vitamin , binding protein , hormone , chemistry , biochemistry , gene
SUMMARY The effects of surgical stress on the metabolism of the retinol‐binding‐protein‐thyroxine‐binding‐prealbumin complex were investigated. The immediate post‐surgical period was characterized by a rapid decline in the serum concentration of retinol, retinol binding protein and triiodothyronine and an increase in the 24 h urinary excretion of retinol, retinol‐binding‐protein and thyroxine. Similar, but less pronounced, changes were seen in other subjects suffering acute myocardial infarction but were not observed in normal healthy euthyroid males or in pre‐operative euthyroid patients. The preparation of specific anti‐retinol binding protein anti‐serum and the use of this in ‘monorocket’ immunoelectrophoresis are also described.