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GROWTH HORMONE MODULATION OF ARGININE‐INDUCED GLUCAGON RELEASE: STUDIES OF ISOLATED GROWTH HORMONE DEFICIENCY AND ACROMEGALY
Author(s) -
SEINO YUTAKA,
TAMINATO TOMOHIKO,
GOTO YASUO,
INOUE YOSHIMICHI,
KADOWAKI SEIZO,
HATTORI MASAHIRO,
MORI KOZABURO,
KATO YUZURU,
MATSUKURA SHIGERU,
IMURA HIROO
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb01515.x
Subject(s) - acromegaly , medicine , endocrinology , glucagon , arginine , hormone , insulin , growth hormone deficiency , growth hormone , somatostatin , biology , amino acid , biochemistry
SUMMARY Plasma glucagon and insulin responses to l ‐arginine were compared in normal controls and patients with isolated growth hormone deficiency and acromegaly. Patients with isolated growth hormone deficiency were characterized by high plasma glucagon response and low plasma insulin response, whereas acromegalic patients showed exaggerated plasma glucagon response and almost normal insulin response. These results suggest that growth hormone is probably required for optimum function of the islets, and since hyperglucagonaemia was observed in both growth hormone deficiency and acromegaly, metabolic disturbances stemming from the respective primary diseases may affect glucagon secretion.