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CHANGES IN PITUITARY GONADOTROPINS DURING THE AMENORRHOEA‐GALACTORRHOEA SYNDROME DUE TO SULPIRIDE
Author(s) -
BUVAT J.,
THOMAS K.,
RACADOT A.,
BLACKER C.,
BUVATHERBAUT M.,
FERIN F.,
LINQUETTE M.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb01507.x
Subject(s) - sulpiride , endocrinology , medicine , prolactin , galactorrhea , gonadotropin , pituitary gland , hormone , antagonist , receptor
SUMMARY Sulpiride, a dopamine receptor blocker which raises prolactin, was given to six women with idiopathic amenorrhoea for 10 days and to eleven women with regular cycles for 3 to 6 months. The latter group developed galactorrhoea and amenorrhoea during treatment. Basal LH and FSH concentrations showed no significant changes. At 3 months but not at 10 days (amenorrhoea group) or 6 months (regular menses group) the area‐under‐the‐curve of LH response to LHRH was increased. FSH responses to LHRH was not altered. The significance of these results to the hyper‐prolactinaemia‐amenorrhoea syndromes are discussed.