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THYROID FUNCTION TESTS IN PATIENTS ON LONG‐TERM TREATMENT WITH VARIOUS ANTICONVULSANT DRUGS
Author(s) -
LIEWENDAHL K.,
MAJURI H.,
HELENIUS TUULA
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb01493.x
Subject(s) - carbamazepine , anticonvulsant , triiodothyronine , endocrinology , medicine , phenytoin , thyroid function , hormone , thyroid , primidone , reverse triiodothyronine , thyroid function tests , free thyroxine , thyroid stimulating hormone , pharmacology , chemistry , epilepsy , psychiatry
SUMMARY Thyroid function tests were studied in patients undergoing long‐term treatment with various anticonvulsant drugs. Previous reports that diphenylhydantoin induces a decrease in the serum concentrations of total and free thyroxine (T4) and tri‐iodothyronine (T3) without a change in the TSH concentration were confirmed. Diphenylhydantoin had no effect on reverse T3. Carbamazepine was also found to decrease serum T4, the free T4 index and T3 but, with the exception of T3, the decrease was smaller than that induced by diphenylhydantoin. Dipropylacetic acid did not influence the serum thyroid hormone concentrations, and neither did primidone. This demonstrates that the interaction between anticonvulsant drugs of different chemical structure and thyroid hormone metabolism is diverse. None of the drugs tested altered serum TSH or the T3 uptake test for the estimation of unsaturated thyroid hormone binding‐capacity in serum. These two tests are considered diagnostically more dependable than the measurement of thyroid hormones in serum when diphenylhydantoin and carbamazepine are administered.