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FAILURE OF SOMATOSTATIN TO DIAGNOSE ORGANIC HYPERINSULINISM
Author(s) -
CASCIO V.,
GALVANINI G.,
ADAMI S.,
CINTI S.,
BIANCHI I.,
COMINACINI L.,
SCURO L. A.
Publication year - 1978
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1978.tb01353.x
Subject(s) - tolbutamide , somatostatin , hyperinsulinism , medicine , endocrinology , insulin , pancreas , insulin resistance
SUMMARY. In four patients with organic hyperinsulinism (two with surgically proven β‐cell adenomas of the body of the pancreas) a standard tolbutamide test during continuous somatostatin infusion (5 μg/min) was carried out. Tolbutamide‐induced insulin release was completely inhibited by somatostatin as in normal subjects. These results suggest that the inhibition test with somatostatin does not seem to be a better or safer way of diagnosing insulin producing tumours.