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EFFECT OF lα‐HYDROXYVITAMIN D 3 AND 1,25‐DIHYDROXYVITAMIN D 3 ON INTESTINE AND BONE IN GLUCOCORTICOID‐TREATED PATIENTS
Author(s) -
LUND B.,
ANDERSEN R. B.,
FRIIS T.,
HJORTH L.,
JØRGENSEN F. S.,
NORMAN A. W.,
SØRENSEN O. H.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03379.x
Subject(s) - medicine , prednisone , endocrinology , vitamin d and neurology , calcium , glucocorticoid , osteoporosis , bone resorption , excretion , absorption (acoustics) , calcium metabolism , rheumatoid arthritis , chemistry , physics , acoustics
SUMMARY The effect of lα‐hydroxyvitamin D 3 (lα‐OHD 3 ) and 1,25‐dihydroxyvitamin D 3 (1,25–(OH) 2 D 3 ) on the intestinal calcium absorption was studied in twenty patients with rheumatoid arthritis treated with prednisone at daily doses of 5–15mg for 1/2–20 years. The fractional calcium absorption, measured before and after the treatment with the vitamin D compounds, increased in nineteen of the twenty patients. This was, however, accompanied by marked rises in the urinary calcium excretion. There was no correlation between the fractional calcium absorption and the duration of the prednisone treatment or the doses given.