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EFFECT OF lα‐HYDROXYVITAMIN D 3 ON PARATHYROID FUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE
Author(s) -
NIELSEN H. E.,
CHRISTENSEN M. S.,
MELSEN F.,
RØMER F. K.,
HANSEN H. E.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03364.x
Subject(s) - medicine , endocrinology , parathyroid hormone , calcium , renal function , vitamin d and neurology , calcium metabolism
SUMMARY The effect of lα‐hydroxyvitamin D 3 (1α‐OHD 3 ) on parathyroid function was studied in sixteen patients (ten on haemodialysis, six with chronic renal insufficiency) during treatment for 6–8 months. During treatment, a decrease in serum parathyroid hormone (s‐PTH) and an increase in serum calcium were seen. An inverse linear correlation was found between serum calcium and logarithmic values of s‐PTH in fifteen of sixteen patients, but the slopes of the regression lines varied considerably. This indicates that the suppression of parathyroid function seen during treatment with lα‐OHD 3 is mediated by a rise in the serum concentration of calcium. For normalization of s‐PTH, the serum concentration of calcium had to be above normal range in several patients, indicating a defect in calcium‐mediated regulation of the secretion of parathyroid hormone. Tlus abnormality was seen especially in long‐term haemodialysed patients.