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VITAMIN D METABOLISM
Author(s) -
DELUCA HECTOR F.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03356.x
Subject(s) - bone remodeling , osteoporosis , vitamin d and neurology , endocrinology , tetany , medicine , metabolism , parathyroid hormone , hormone , calcium
SUMMARY During the past decade, an explosion of information has become avdable on the metabolism and function of vitamin D whch is of great importance to clinicians in the treatment of metabolic bone disease. We have learned that vitamin D is the precursor of at least one hormone and that ths hormone carries out functions in calcium and phosphorus metabolism brmging about mineralization of bone on one hand, and the prevention of hypocalcaemic tetany on the other. It may also function in the prevention of such degenerative bone diseases as osteoporosis. An important analogue of this hormone, lα‐hydroxyvitamin D 3 has been prepared and is used successfully in the treatment of a variety of clinical conditions. This presentation will summarize these findings and their possible implications in these metabolic bone diseases.