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PROLACTIN SECRETION IN GIRLS WITH ISOLATED GONADOTROPHIN DEFICIENCY
Author(s) -
PERTZELAN A.,
ASSA S.,
KERET R.,
LARON Z.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03353.x
Subject(s) - prolactin , endocrinology , medicine , basal (medicine) , microgram , secretion , thyrotropin releasing hormone , hormone , biology , chemistry , in vitro , biochemistry , insulin
SUMMARY Plasma prolactin, basal levels and the response to an i.v. injection of TRH (100 μ/m 2 ) was determined in five girls with isolated gonadotrophin deficiency of hypothalamic origin before and after at least 3 months cyclic replacement therapy with conjugated oestrogens(1.25 rng/day). The basal plasma prolactin levels were similar during both tests, however, during oestrogen therapy the mean peak response to TRH almost doubled and the sum of all the values obtained (basal, +15, +30 and +60 min) was significantly higher. It is of note that even upon prolonged oestrogen deprivation the releasable prolactin response to TRH was adequate.