Premium
INCREASING GROWTH WITH RAISED CIRCULATING SOMATOMEDIN BUT NORMAL IMMUNOASSAYABLE GROWTH HORMONE
Author(s) -
HOFFENBERG R.,
HOWELL A.,
EPSTEIN S.,
PIMSTONE B. L.,
FRYKLUND L.,
HALL K.,
SCHWALBE S.,
RUDD B. T.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03327.x
Subject(s) - somatomedin , medicine , endocrinology , kyphoscoliosis , growth hormone , hormone , biology , surgery , scoliosis
SUMMARY Two patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One, a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.