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REDUCTION OF PLASMA TRIIODOTHYRONINE (T3) INDUCED BY PROPRANOLOL
Author(s) -
LOTTI GAETANO,
DELITALA GIUSEPPE,
DEVILLA LUISA,
ALAGNA SERGIO,
MASALA ANTONIO
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03322.x
Subject(s) - propranolol , triiodothyronine , endocrinology , medicine , reverse triiodothyronine , hormone , metabolism , thyroid , oral administration , chemistry
SUMMARY The effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and triiodothyronine uptake by Sephadex G‐25 (RT3U%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 day course of treatment with propranolol. These results suggest that propranolol has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretion.