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REDUCED‘GONADOTROPHS RESPONSE TO RELEASING HORMONE’AFTER CHRONIC ADMINISTRATION TO IMPOTENT MEN
Author(s) -
DAVIES TERRY F.,
GOMEZPAN A.,
WATSON M. J.,
MOUNTJOY C. Q.,
HANKER J. P.,
BESSER G. M.,
HALL REGINALD
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03317.x
Subject(s) - endocrinology , medicine , prolactin , testosterone (patch) , gonadotropic cell , hormone , luteinizing hormone , chemistry
SUMMARY Ten endocrinologically normal men with secondary sexual impotence were given 500 μg LHRH subcutaneously every 8 h. After 4 weeks treatment the LH response to 500 μg LHRH was reduced from a peak of 35.7 ± 5.2 to 16.8 ± 3.5 mu/ml (P< 0.01) and the FSH response from 4.2 ± 0.93 to 2.39 ± 0.4 mu/ml (P< 0.01). Circulating total testosterone, oestradiol, prolactin and sex hormone binding globulin showed no significant changes. Whether this inability of the pituitary to maintain its response to LHRH is peculiar to impotent men requires further study.