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THYROID‐STIMULATING IMMUNOGLOBULINS IN OPHTHALMIC GRAVES'DISEASE
Author(s) -
TENG C. S.,
SMITH B. REES,
CLAYTON B.,
EVERED D. C.,
CLARK F.,
HALL R.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb03316.x
Subject(s) - medicine , antibody , thyroid , endocrinology , graves' disease , thyroid function , receptor , thyrotropin receptor , autoimmune disease , anti thyroid autoantibodies , thyroid function tests , disease , immunology , autoantibody
SUMMARY Thyroid‐stimulating immunoglobulins (TSI) have been detected by receptor assay in the sera of 43% of patients with ophthalmic Graves’disease. Comparison of the receptor assay studies with thyroid function tests indicated that in several patients the antibodies detected by receptor assay were biologically inactive. In other patients, thyroid function appeared to be under TSI control with hyperthyroidism prevented by autoimmune destruction of the thyroid.