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THE EFFECTS OF HALOTHANE ON PLASMA VASOPRESSIN DURING CARDIO‐PULMONARY BYPASS
Author(s) -
SIMPSON PETER,
FORSLING MARY
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb02937.x
Subject(s) - vasopressin , medicine , halothane , endocrinology , cardiorespiratory fitness , cardiology , anesthesia
SUMMARY Plasma vasopressin concentrations were estimated in twelve patients undergoing cardio‐pulmonary bypass for open heart surgery. In six patients anaesthesia was maintained with 66% nitrous oxide in oxygen, whilst the remaining six additionally received halothane as a vasodilator during the bypass period. Induction of anaesthesia had little effect on plasma vasopressin concentrations, whilst marked increases were seen during surgery and bypass in both groups of patients. However, in those patients receiving halothane, significantly higher concentrations were reached, a maximum 36.1 ± 8.9 (SEM) μu/ml being seen in contrast to 15.4 ± 2.2 μu/ml in the group receiving nitrous oxide in oxygen alone.