Premium
THE CARDIOVASCULAR AND LIPID STATUS OF PERNICIOUS ANAEMIA PATIENTS WITH AND WITHOUT THYROID ANTIBODIES
Author(s) -
RAMSAY IAN,
KRASSAS G.,
McHARDYYOUNG S.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb02006.x
Subject(s) - medicine , endocrinology , thyroid , antibody , pernicious anaemia , anti thyroid autoantibodies , thyroid dysfunction , autoantibody , immunology
SUMMARY A study has been undertaken of the cardiovascular and lipid status of patients with pernicious anaemia (PA). There was no evidence of elevated cholestrol, triglyceride and lipoprotein concentrations nor of an increased prevalence of ischaemic heart disease and peripheral vascular disease in those patients who had positive thyroid antibodies compared with those who had not. There were also no significant differences in cardiovascular or lipid status in the antibody positive patients between those who had an exaggerated thyroid stimulating hormone (TSH) response to thyrotrophin releasing hormone (TRH) and those who had a normal or impaired response. It is suggested that an exaggerated response to TRH in these PA patients usually indicates ‘compensated euthyroidism’ and not ‘subclinical hypothyroidism’ or ‘premyxoedema’ and that they are no more at risk for cardiovascular disease than are PA patients with no evidence of thyroid abnormality.