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THE EFFECT OF INSULIN ON LUNG METABOLISM IN THE RAT
Author(s) -
STUBBS W. A.,
MORGAN I.,
LLOYD B.,
ALBERTI K. G. M. M.
Publication year - 1977
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1977.tb01313.x
Subject(s) - medicine , endocrinology , insulin , perfusion , metabolism , lung , carbohydrate metabolism , chemistry , biology
SUMMARY A new model has been established for the perfused in situ rat lung. During perfusion with glucose at 4 mmol/1, physiological concentrations of insulin (50 mu/1) caused an initial 1.5 fold increase in lactate production; the increase being sustained at 30% for the 4 h of perfusion. The observation that the lung responds to physiological concentrations of insulin could have important implications with respect to whole body carbohydrate metabolism.