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BROMOCRIPTINE POTENTIATION OF GASTRIC ACID SECRETION IN CATS
Author(s) -
HIRST BARRY H.,
REED J. DAVID,
GOMEZPAN ANTONIO,
LABIB L. ALBERT
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb03876.x
Subject(s) - long term potentiation , bromocriptine , endocrinology , medicine , cats , secretion , gastric acid , biology , hormone , prolactin , receptor
Summary Bromocriptine administered both orally and intravenously potentiated gastric acid secretion in response to submaximal pentagastrin stimulation in cats. Bromocriptine did not increase the maximum acid secretion in response to pentagastrin, nor did it stimulate basal acid secretion. Potentiation was observed in normal and vagotomized animals which precludes involvement of the vagi in the response. The mechanism of action of this compound on the stomach does not appear to be mediated through stimulation of dopaminergic receptors as no potentiation was observed with dopamine infusions. It is argued that the bromocriptine potentiation of gastric acid secretion may be a demonstration of 5‐hydroxytryptamine or a‐adrenergic antagonism. However, the potentiation observed with daily oral bromocriptine treatment had disappeared by the eighth day and may correlate with the disappearance of gastric side effects noted in patients on bromocriptine treatment.