Premium
ROLE OF GLUCAGON IN HUMAN DIABETIC KETOACIDOSIS: STUDIES USING SOMATOSTATIN
Author(s) -
GERICH JOHN E.,
SCHNEIDER VICTOR S.,
LORENZI MARA,
TSALIKIAN EVA,
KARAM JOHN H.,
BIER DENNIS M.,
FORSHAM PETER H.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb03838.x
Subject(s) - medicine , glucagon , endocrinology , diabetic ketoacidosis , somatostatin , endogeny , insulin , ketoacidosis , ketogenesis , diabetes mellitus , ketone bodies , metabolism , type 1 diabetes
SUMMARY The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis. Furthermore, continuous elevation of endogenous glucagon secreation appears to be necessary for the maintenance and continued development of the characteristic metabolic consequences of insulin lack.